PUBLICATIONS

Featured Publications

Lifestyle Influences the Gut Microbiome in Children

Body mass index (BMI) level, exercise frequency, and type of diet individually impacted children’s gut microbiota after controlling for age, sex, and use of antibiotics and probiotics. Actinobacteria phylum had significantly depleted operational taxonomic units (OTUs) with respect to BMI level, diet type, and exercise frequency. Proteobacteria phylum had significantly enriched OTUs for higher BMI level and Firmicutes phylum had significantly enriched OTUs for more exercise.

Gut Microbiome-Metabolomic Pathways Associated with Psychoneurological Symptom Cluster in Children with Solid Tumors

Using multi-omics approaches, this study indicated specific microbiome–metabolome pathways linked with PNS in children with cancer across chemotherapy. Gut bacteria with potential probiotic functions, along with fatty acid metabolism, tryptophan, and carnitine shuttle, were more clustered in cancer cases than the control network, which potentially linked with psychoneurological symptoms in chemotherapy.

Gut Microbiome Associated with Psychoneurological Symptoms in Patients with Head and Neck Cancer

The high level of psychoneurological symptom cluster was more abundant with phylum Bacteroidetes, order Bacteroidales, class Bacteroidia, and four genera (Ruminiclostridium9, Tyzzerella, Eubacterium_fissicatenagroup, and DTU089), while the low level psychoneurological symptom group was more abundant with family Acidaminococcaceae and three genera (Lactococcus, Phascolarctobacterium, and Desulfovibrio).

Circulating Metabolites Associated with Psychoneurological Symptoms in Children with Cancer

Fatty acids pathways were associated with pain: de novo fatty acid biosynthesis, fatty acid metabolism, fatty acid activation, and omega-3 fatty acid metabolism. Tryptophan amino acid pathway was associated with fatigue, anxiety, and the psychoneurological symptoms cluster. Carnitine shuttle was associated with the psychoneurological symptom cluster.

Neighborhood Socioeconomic Deprivation Determined Cancer Survival and Outcomes

After analyzing 751 men with prostate cancer participating trial NRG RTOG 0415, area-level inequities were associated with patient-reported outcomes (i.e., sexual health, pain, self-care, and quality of life) and disease-free survival among patients with early-stage prostate cancer.

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(*refereed publications, +data-based publications, ^mentee/student, §senior author, #invited publications, editorial/letter/report, published in Chinese)